Email lpt.research@nhs.net to find out more about the studies below.

RESTORE-LIFE, Treatment Resistant Depression

This study aims to assess whether vagal nerve stimulation is effective as an adjunctive therapy in patients that have treatment resistant depression.

One in three people with a history of depression have not responded to treatment (NICE, 2018). RESTORE-LIFE involves the surgical implantation of a pulse generator into the chest of the participant. This generator connects to and stimulates the vagus nerve for a set period of time. The study aims to see whether this nerve stimulation is effective as treatment in people with treatment resistant depression.

PI: Dr Ganesh Kunjithapatham.
R&D Delivery Team: Jo Edgar and Jo McGarr

 

LIRO, Psychiatric Rehabilitation Services

Leicestershire Inpatient Rehabilitation Outcomes (LIRO) aims to analyse data of service users who have accessed psychiatric rehabilitation services in Leicestershire.

LIRO aims to understand what helps individuals successfully progress from rehabilitation services into a community setting. Understanding outcomes is beneficial to patients accessing such services, service providers and commissioners. The study is led by Chief Investigator Dr Kelly Fenton alongside Dr Sandeep Singh and Dr Kat Kidd from the Enhanced Rehabilitation and Recovery Pathway in LPT.

 

 

ImPreSs-care, Physical Health of Older People

ImPreSs-care aims to determine the physical health care needs of older adult patients under mental health services.

The rationale for this study is to improve the understanding of the physical health needs of older people under mental health services, and how we might be able to reduce admission to acute trusts through a geriatric liaison service.

PI: Hari Subramaniam.
R&D Delivery Team: Debbie Glancy

 

 

ADEPT-2, Depression in Autism

The ADEPT-2 study is investigating if guided self-help (GSH) is helpful in reducing depression experienced by autistic adults.

Effective treatments for depression exist and include low-intensity cognitive behaviour therapy (CBT). CBT is a psychological (talking) therapy. This is often called guided self-help. Research shows that guided self-help can be helpful for depression for non-autistic adults, but it is not clear if it is also helpful for autistic adults. This study hopes to establish the effectiveness of an adapted low intensity psychological intervention for depression in autistic adults. The Principal Investigators for this study are Dr Sam Tromans and Dr Mary Barrett. Click here to find out more: https://adept.blogs.bristol.ac.uk/

PI: Dr Mary Barrett and Dr Sam Tromans.
R&D Delivery Team: Dr Sarah Baillon, Joy Fellows, Tom Pringle, Jo Brown

 

 

STRATA, Autism

STRATA intends to investigate whether Sertraline could be an effective treatment for anxiety in adults with a diagnosis of autism, compared to placebo.

STRATA is the largest study of its kind, and will take place across 5 regions in England and Western Australia. The Principal Investigators for this study are Dr Ganesh Kunjithapatham and Dr Asit Biswas. This study is no longer open to recruitment in LPT. You can find out more about this research here: https://strata.blogs.bristol.ac.uk/

PI: Dr Ganesh Kunjithapatham and Dr Asit Biswas
Delivery Team: Zoe Morgan Dr Sarah Baillon, Dr Sam Tromans, Joy Fellows

 

 

GLAD, Anxiety and Depression

The Genetic Links to Anxiety and Depression (GLAD) study hopes to better understand depression and anxiety in order to find better treatments and improve people's lives.

Participants in GLAD complete an online questionnaire and send a saliva DNA sample to the study team through the post. Those participating in GLAD can choose to be involved in the COPING study, investigating the effect of COVID-19 on mental and neurological health. Find out more here: https://gladstudy.org.uk/.

 

 

ADEPP, Depression after First Episode in Psychosis

The aim of the ADEPP trial is to establish the effectiveness and cost effectiveness of an antidepressant medication (sertraline) for prevention of a depressive episode following first episode psychosis.

Sertraline is a commonly used antidepressant which has been shown to prevent depression in other conditions. ADEPP is a multi-centre, double-blinded, randomised placebo controlled trial to investigate if taking sertraline in addition to usual treatment for 6 months after first episode psychosis can help to reduce the chances of depression as a preventative measure. The Lead Investigator for this study in LPT is Dr Shiraz Ahmed. Click here to find out more: https://www.birmingham.ac.uk/research/bctu/trials/pd/adepp/index.aspx

PI: Dr Shiraz Ahmed
R&D Delivery Team: Jo Edgar, Tom Pringle

 

 

Digital Health Tools in Psychosis, Mental Health Services

This study consists of a short anonymous survey to find out what people think about wearing a digital device to help manage mental health

The Digital Health Tools in Psychosis study aims to investigate the view of service users with a diagnosis of schizophrenia or psychosis, or healthcare professionals who have worked with these individuals about using digital health tools such as a smart phone (iPhone or Android Phone) or wearable device (Fitbit or smart watch) in mental health.

PI: Dr Nandini Chakraborty
R&D Delivery Team: Jo Edgar

 

 

Exploring Bipolar Disorder and its relationships with interoception and emotion recognition, Mental Health Services

This research study aims to explore bipolar disorder and its potential relationship with emotion recognition and detecting bodily sensations

This study is being conducted by Paul Mulvenna (PhD student at De Montfort University). Findings from this study will be useful in providing a direction for future research and the development of effective interventions and diagnosis for individuals with bipolar disorder. This study is being supported by Dr Suneeta James as clinical supervisor. 

 

 

Ethnic variations in outcomes of patients seen in Leicester memory service between 2013 and 2021, Memory Services

This study is investigating factors which differ between ethnic groups of patients seen in memory clinic, and whether outcomes differ by ethnicity.

Leicester has a large population of ethnic minorities. Understanding ethnic variations in outcomes of patients seen in memory services will be aid the design and development of dementia services for areas with a high proportion of patients presenting from Black and South Asian backgrounds. This research mat help to identify inequalities which can be addressed. This research is led by Dr Hari Subramaniam.

 

 

 

Understanding anger and aggression: a questionnaire study, Mental Health Services

There are lots of reason people might get angry or become aggressive. We want to understand these better so we can support people better and improve treatments to reduce violence.

Although most people with psychosis are never violent, for a proportion of patients aggression is an important clinical issue. This questionnaire study aims to measure anger and aggression and a number psychological mechanisms that the researchers think might be key drivers for aggression. Participants do not need to have had experiences with anger or violence to take part in this study. All experiences are equally helpful to our research.

PI and Co-Investigators: Dr Kelly Fenton, Jacqui Newton, Dr Shiraz Ahmed and Debbie Tombs.
R&D Delivery Team: Jo Edgar, Tom Pringle, Joy Fellows

 

 

Thoughts about physical activity: a questionnaire study, Mental Health Services

This questionnaire study aims to find out what people with psychosis think about physical activity

Being physically active can be helpful for physical and mental health, but people with psychosis have told the study team at the University of Oxford that doing physical activity can be really challenging. This study aims to develop and validate four new questionnaires to assess the thoughts people with psychosis have about physical activity.

PI and Co-Investigators: Dr Kelly Fenton, Jacqui Newton, Dr Shiraz Ahmed and Debbie Tombs.
R&D Delivery Team: Jo Edgar, Tom Pringle, Joy Fellows

 

 

 

NCISH, Suicide

The National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH) has collected in-depth information on all suicide in the UK since 1996.

The data from NCISH has helped to inform patient safety in mental health settings, which in turn has helped to contribute to an overall reduction in suicide in the UK. This study is led by the Medical Director in LPT. More details about this enquiry can be found here: https://sites.manchester.ac.uk/ncish/

The information on this page is correct as of November 2023.

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