TRICEPS study summary

Many stroke survivors experience arm weakness. The TRICEPS study is investigating whether stimulating the vagus nerve using a small earpiece alongside rehabilitation therapy can improve arm function in patients with arm weakness after a stroke.

MiFoot studies summary

LPT’s Podiatry Team are supporting recruitment to studies involving patients with diabetic foot ulcers. The MiFoot study is testing a programme designed to improve heart health in people with diabetes and diabetes-related foot ulcers. Whilst the DFU Survey study aims to better understand and characterise the diabetic foot ulcer (DFU) patient population.

Better Conversations with primary progressive aphasia (BCPPA) study summary

Better Conversations with primary progressive aphasia (BCPPA) is a short speech and language therapy programme for people with PPA or other language-led dementias and a family member or communication partner. Across four sessions, a speech and language therapist helps identify what supports or hinders everyday conversations and practise simple strategies to improve
communication and confidence..

RESTORE studies summary

ReSTORe is a research study testing a supervised, live, online group rehabilitation programme for people living with ongoing physical or mental health difficulties after stroke. The study aims to find out whether this home-based programme can improve quality of life and wellbeing compared with usual care, for people 6 to 36 months after leaving hospital.

Personal Agility studies summary

The PERSONAL-AGILITY study is testing a personalised, technology-supported programme to help adults living with multiple long-term conditions and frailty improve their daily movement, reduce sitting time, and support better sleep. The 24-week study will assess whether this flexible, shared decision-making approach, which also involves carers and community support is practical, acceptable  and suitable for testing in a larger national trial.

Restore Life study summary

One in three people with a history of depression have not responded to treatment (NICE, 2018). RESTORE-LIFE aims to assess whether vagal nerve stimulation is effective as an adjunctive therapy in patients that have treatment resistant depression. This involves the surgical implantation of a pulse generator in the chest connected to the vagus nerve that stimulates the nerve for a set period of time.

BBDLB study summary

It is important to differentiate between different types of dementia, as treatments and the risks associated differ. Dementia with Lewy bodies (DLB) is a subtype of dementia but is under-researched compared to Alzheimer’s disease (AD). This study aims to identify blood-based biomarkers which will help to differentiate between DLB and AD.

HealthE-RND study summary

HealthE-RND aims to develop an eHealth platform to improve quality of life in people affected by rare diseases. Over 3 years the study team aims to develop an eHealth platform and a quality-of-life questionnaire. The study is currently focusing on Huntington’s disease, to study whether the platform is useful.

Sleeping Better study summary

Sleeping Better is a study testing whether a short course of talking therapy for sleep problems can help people who are at risk of, or already experiencing, psychosis. Many people with psychosis struggle with poor sleep, which can make symptoms and daily life harder. This study will see if improving sleep also improves mood, thinking, and overall wellbeing, helping people feel and function better in their everyday lives.

Read Out study summary

READ-OUT is a UK study exploring whether simple blood tests can help detect and monitor dementia in people with memory or thinking difficulties. It involves over 3,000 participants aged 45 and above, and looks at how accurate, acceptable, and cost‑effective these tests are in everyday healthcare. The aim is to make dementia diagnosis quicker and easier and improve care for those affected.

Enroll-HD study summary

Enroll-HD is a worldwide observational study open to people with, or at risk of, Huntington’s disease. It aims to understand the experience of those living with Huntington’s disease and how the disease changes over time. This study has been open in LPT for more than 10 years.

Later Stage HD assessments study summary

This study aims to develop tools to see how the later stages of Huntington’s disease affect individuals. The study is evaluating two common assessments that have been adapted for telephone interview. This study is open to Enroll-HD participants who are in mid- to later stages of HD and their companions.

NCISH study summary

The National Confidential Inquiry into Suicide and Safety in Mental Health (NCISH) study collects detailed information on all suicides in the UK, the findings from this work have helped to improve patient safety in mental health settings.

CareCoach study summary

This study is evaluating an online support package aimed at anyone who has caring responsibilities for a person living with dementia compared to usual care. The intervention involves learning modules with remote support from a coach.

GLAD study summary

The Genetic Links to Anxiety and Depression (GLAD) study aims to better understand depression and anxiety in order to find better treatments and improve the lives of people experiencing these disorders. Participants in this study complete an online questionnaire and send a saliva DNA sample to the study team through the post.

ORLO study summary

The ORLO study is investigating the outcomes of people after they leave mental health rehabilitation inpatient services, and if these outcomes might be influenced by other factors including their gender, ethnicity or the clinical team providing their care. The results from this research study may help to improve services going forward.

FAST study summary

The FAST study is a research project investigating whether simple blood tests and online cognitive assessments can help improve dementia screening and monitoring. The study will assess how practical and acceptable these methods are for large-scale use and explore whether specific blood biomarkers are linked to memory problems or dementia diagnoses,
helping to inform the development of future larger studies.

EMBRACE study summary

The EMBRACE study explores ways to support parents with psychosis or bipolar disorder in building confidence and strengthening their bond with their young children. Using a method called video feedback, parents and a therapist review short clips of everyday interactions to help parents recognize and build on positive moments with their child. This small study aims to see if parents are willing to take part and to understand their experiences, helping determine whether a larger study should be conducted and how best to do it .

EDGI study summary

Eating Disorders Genetics Initiative (EDGI) is the largest ever genetic research study of eating disorders, to understand how genes can influence an individual’s risk for developing bulimia nervosa, binge-eating disorder and anorexia nervosa. The EDGI Study is open to anyone over the age of 16 who has experienced or is currently experiencing an eating disorder. Participants in EDGI will provide a saliva DNA sample and complete a series of online questionnaires.

Further information can be found here: https://edgi.org/

ROBUST study summary

The ROBUST study is a clinical trial designed to evaluate whether a specially developed exercise programme to strengthen the muscles of young people aged 12 – 18 years diagnosed with spastic cerebral palsy, is better than usual NHS physiotherapy treatment. This study will be supported locally by the Research Delivery Team and the Children’s Physiotherapy Service.

STAR-CAT study summary

The STAR-CAT study is testing whether OSI-A (an online parent-led intervention) can support autistic children experiencing anxiety problems. In this study, families will be randomly allocated to receive OSI-A or treatment as usual. This study will be supported by the Mental Health Support Teams in Schools (MHST) in the Trust.

SPELL study summary

The SPELL study is a research study designed to evaluate whether a specially developed dynamic stretching exercise programme for children aged 4 -11 years with a diagnosis of spastic cerebral palsy is better when compared to usual NHS physiotherapy treatment. This study will be supported locally by the Research Delivery Team and the Children’s Physiotherapy Service.

Unlocking Excellence study summary

The Unlocking Excellence study is a research project that aims to improve mental health care for people with intellectual disabilities who live in the community. People with intellectual disabilities often face higher rates of mental health issues and barriers to getting the right support. This study will look at current practices, understand the challenges faced by healthcare workers and listen to the experiences of individuals and their families. The goal is to find effective ways to deliver better mental health services, reduce unnecessary hospital stays and develop recommendations to make community mental healthcare more accessible, personalised and effective for this group.

REAL FOODS study summary

REAL FOODS is a research study exploring whether using blended “real” family foods for children who are tube-fed is safe, practical, and beneficial. The study will work with families of children aged 3–11 who require long-term tube feeding, looking at how using blended foods at home affects children’s digestion, health, and overall wellbeing. It will also explore families’ experiences, including the social and emotional impact, and aim to make this approach more accessible to all families. The findings will help guide future research and improve feeding options for children who rely on tube feeding.

DAPPLE study summary

The DAPPLE study aims to improve the quality and accessibility of Palliative and End of Life Care (PEOLC) for people with a learning disability by developing robust, co-produced guidance for health and social care services. Through comprehensive analysis of national data, evidence reviews, case studies and stakeholder engagement, DAPPLE seeks to identify effective models of care, barriers and enablers to timely and personalised PEOLC. Its goal is to produce actionable recommendations, practical resources and inclusive guidance that address inequalities, enhance service coordination and ensure that people with a learning disability receive compassionate, appropriate end-of-life support tailored to their needs.

CeCiliA study summary

CeCiliA is a national research study evaluating whether Care (Education) and Treatment Reviews (C(E)TRs) actually help people with learning disabilities and autistic people avoid unnecessary psychiatric hospital admissions or leave hospital sooner. It brings together lived experience, surveys, interviews and long-term NHS data to understand what works, what doesn’t, and at what cost and will co-produce clear good practice guidance with people with lived experience, families and charities to improve how C(E)TRs are done in the future.