Email lpt.research@nhs.net to find out more about the studies below.
RESTORE-LIFE, Treatment Resistant Depression
RESTORE-LIFE study aims to assess whether vagal nerve stimulation is effective as an adjunctive therapy in patients that have treatment resistant depression.
One in three people with a history of depression have not responded to treatment (NICE, 2018). RESTORE-LIFE aims to assess whether vagal nerve stimulation is effective as an adjunctive therapy in patients that have treatment resistant depression. This involves the surgical implantation of a pulse generator in the chest connected to the vagus nerve that stimulates the nerve for a set period of time.
PI: Dr Ganesh Kunjithapatham.
R&D Delivery Team: Jo Edgar and Jo McGarr
LIRO, Psychiatric Rehabilitation Services
Leicestershire Inpatient Rehabilitation Outcomes (LIRO) aims to analyse data of service users who have accessed psychiatric rehabilitation services in Leicestershire.
The Leicestershire Inpatient Rehabilitation Outcomes (LIRO) study aims to analyse inpatient rehabilitation service user data in LPT. This is to explore who the service users are, what outcomes they achieve and what their rehabilitation pathway looks like. This study is sponsored by LPT and is being run by Chief Investigator Dr Kelly Fenton alongside Dr Sandeep Singh and Dr Kat Kidd from the Enhanced Rehabilitation and Recovery Pathway.
GLAD, Anxiety and Depression
The Genetic Links to Anxiety and Depression (GLAD) study hopes to better understand depression and anxiety in order to find better treatments and improve people's lives.
The Genetic Links to Anxiety and Depression (GLAD) study aims to better understand depression and anxiety in order to find better treatments and improve the lives of people experiencing these disorders. Participants in this study complete an online questionnaire and send a saliva DNA sample to the study team through the post.
R&D Delivery Team: Jo Edgar, Tom Pringle
BBDLB, Dementia
The BBDLB study aims to identify blood-based biomarkers to differentiate between types of dementia
It is important to differentiate between different types of dementia, as treatments and the risks associated differ. Dementia with Lewy bodies (DLB) is a subtype of dementia, but is under-researched compared to Alzheimer’s disease (AD). This study aims to identify blood-based biomarkers which will help to differentiate between DLB and AD.
Principal Investigator: Prof. Elizabeta Mukaetova Ladinska
Research Delivery Team: Dr Sarah Baillon, Tom Pringle, Victory Olutuase, Naomi Gurr
VISION QUEST, Psychosis
VISION QUEST aims to understand visual hallucinations in people with psychosis
One in three people with psychosis have visions, also known as visual hallucinations, though only little is known about these experiences. VISION-QUEST aims to develop the understanding of visions in two ways. Firstly, by developing a new measure exploring peoples beliefs about visions and secondly, by exploring the relationships between visions and other issues. The study is open to people with psychosis aged between 16 – 65 who are currently experiencing visions.
Principal Investigator: Dr Kelly Fenton
Research Delivery Team: Jo McGarr, Tom Pringle
Co-PICS, Psychosis
Co-PICS explores how people from diverse ethnic backgrounds experience and cope with multiple conditions including psychosis
Co-PICS aims to improve the care of diverse people living with psychosis and multiple long-term conditions. This will be done by learning about their experiences followed by the co-design of resources. The resources developed will then be evaluated in their use and impact across England.
Principal Investigator: Dr Shiraz Ahmed
Research Delivery Team: Jo Brown, Naomi Gurr
DREAMS, Domestic Abuse
The DREAMS Study explores how to help mental health professionals identify and support victims of domestic abuse
DREAMS aims to understand how mental health practitioners identify and assist clients experiencing domestic abuse. The study uses surveys and interviews to focus on how mental health professionals identify and assist clients experiencing domestic abuse in intimate relationships, regardless of gender.
Principal Investigator: Dr Lois Dugmore
Research Delivery Team: Jo Brown
TRAUMA-AID, Intellectual Disabilities
TRAUMA-AID is a Randomised Controlled Trial of an adapted EMDR protocol compared to treatment as usual in adults with intellectual disabilities
TRAUMA-AID is a randomised controlled trial to investigate Eye Movement Desensitisation and Reprocessing (EMDR) for symptoms of Post-Traumatic Stress Disorder (PTSD) in adults with intellectual disabilities. This study aims to evaluate whether EMDR provides value for money, improves the mental health and quality of life for people with intellectual difficulties who suffer PTSD when compared to standard available treatment.
Principal Investigator: Dr Peter Beardsworth
Research Delivery Team: Jo Brown
Antipsychotic Induced MSEs, Psychosis
The antipsychotic induced MSEs study aims to characterise changes in behaviour when taking an antipsychotic medication which lead to metabolic side effects
This study aims to investigate changes in the behaviour of people taking antipsychotic medication that leads to the development of metabolic side effects, including weight gain, high cholesterol and high blood sugars. People who get metabolic side effects are at high risk of getting type 2diabetes and heart disease. Individuals who have recently started taking,or are about to start taking, an antipsychotic medication and their family member, friend or carer will be invited to take part.
Principal Investigator: Dr Dolly Sud
Research Delivery Team: Joy Fellows, Victory Olutuase
Identifying and exploring positively deviant staff members, to explore exceptional smoking cessation practice for people with Severe Mental Illness (SMI)., Mental Health
This study will support the development of best practice for smoking cessation for people with severe mental illness
The purpose of this project is to understand the most effective smoking cessation practices in supporting people with severe mental illness (SMI) to quit smoking. The research team aim to use this information to develop a gold standard for best practice of smoking cessation for people with SMI.
Principal Investigator: Dr Emily Lucocq
TEMPLR, Dementia
The TEMPLR study will investigate whether performance on eye movement and pupillometry tasks is an early indicator of cognitive impairment
The Tracking Eye Movement and Pupil Light Response in dementia (TEMPLR) study aims to identify if the performance on eye movement and pupillometry tasks can be used as an early indicator of cognitive impairment in Alzheimer’s disease and mild cognitive impairment. If so, these tasks may be able to be used as a diagnostic tool.
Principal Investigator: Prof. Elizabeta Mukaetova-Ladinska
NCISH, Suicide
The National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH) has collected in-depth information on all suicide in the UK since 1996.
The data from NCISH has helped to inform patient safety in mental health settings, which in turn has helped to contribute to an overall reduction in suicide in the UK. This study is led by the Medical Director in LPT. More details about this enquiry can be found here: https://sites.manchester.ac.uk/ncish/
The information on this page is correct as of December 2024.