Email lpt.research@nhs.net to find out more about the studies below.

Enroll-HD, Huntington's disease

Enroll-HD is a worldwide observational study open to people with, or at risk of, Huntington’s disease (HD).

Enroll-HD is a resource for all Huntington’s disease research, which aims to understand the experience of those living with HD and how the disease changes over time. This study aims to better understand the disease as it happens in people, to hopefully provide insights into new drugs or treatments for HD. The Principal Investigator for this study is Dr Reza Kiani. You can find out more here: https://www.enroll-hd.org/

 

 

GUIDE-HD, Huntington's disease

GUIDE-HD hopes to investigate whether a new talking therapy aimed at reducing anxiety for Huntington’s disease gene carriers could be beneficial.

Anxiety is a distressing problem experienced by around 71% of Huntington’s gene carriers. Anxiety damages quality of life and can worsen other Huntington’s symptoms. Guided self-help can help people who are anxious, and involves offering people information on how to manage their anxiety, and providing therapy sessions by telephone, video-conferencing or email. GUIDE-HD is a feasibility trial of a new talking therapy to see what people think about the therapy, and the project design, before undertaking a larger study involving more participants. The Chief Investigator for this study is Dr Maria Dale.

 

 

HealthE-RND, Neurodegeneration and Huntington's disease

HealthE-RND aims to develop an eHealth platform to improve quality of life in people affected by rare diseases.

Over 3 years the study team aims to develop an eHealth platform and a quality of life questionnaire. The study is being carried out in 6 European countries, focusing on HD in the first instance, to study whether the platform is useful. HeathE-RND is led by Dr Maria Dale in LPT. You can find out more about this study here: https://healthe-rnd.eu/

 

 

iMARK-HD, Huntington's disease

iMARK-HD is a study designed to assess changes in the brain as a result of Huntington's Disease using two types of imaging scans, PET and MRI.

The main purpose of this study is to find a biomarker for HD using imaging scans. A biomarker is an indicator of the presence of a disease or a condition, that can be measured, and that is able to give information about the progression, or severity, of this condition. There is currently no biomarker identified for HD. Finding a biomarker may assist in the development of a treatment. The Principal Investigator for this study in Dr Reza Kiani.

 

 

ADEPT-2, Depression in Autism

The ADEPT-2 study is investigating if guided self-help (GSH) is helpful in reducing depression experienced by autistic adults.

Effective treatments for depression exist and include low-intensity cognitive behaviour therapy (CBT). CBT is a psychological (talking) therapy. This is often called guided self-help. Research shows that guided self-help can be helpful for depression for non-autistic adults, but it is not clear if it is also helpful for autistic adults. This study hopes to establish the effectiveness of an adapted low intensity psychological intervention for depression in autistic adults. The Principal Investigators for this study are Dr Sam Tromans and Dr Mary Barrett. Click here to find out more: https://adept.blogs.bristol.ac.uk/

 

 

NCISH, Suicide

The National Confidential Inquiry into Suicide and Homicide by People with Mental Illness (NCISH) has collected in-depth information on all suicide in the UK since 1996.

The data from NCISH has helped to inform patient safety in mental health settings, which in turn has helped to contribute to an overall reduction in suicide in the UK. This study is led by the Medical Director in LPT. More details about this enquiry can be found here: https://sites.manchester.ac.uk/ncish/

 

 

GLAD, Anxiety and Depression

The Genetic Links to Anxiety and Depression (GLAD) study hopes to better understand depression and anxiety in order to find better treatments and improve people's lives.

Participants in GLAD complete an online questionnaire and send a saliva DNA sample to the study team through the post. Those participating in GLAD can choose to be involved in the COPING study, investigating the effect of COVID-19 on mental and neurological health. Find out more here: https://gladstudy.org.uk/.

 

 

RESTORE-LIFE, Treatment Resistant Depression

This study aims to assess whether vagal nerve stimulation is effective as an adjunctive therapy in patients that have treatment resistant depression.

One in three people with a history of depression have not responded to treatment (NICE, 2018). RESTORE-LIFE involves the surgical implantation of a pulse generator into the chest of the participant. This generator connects to and stimulates the vagus nerve for a set period of time. The study aims to see whether this nerve stimulation is effective as treatment in people with treatment resistant depression.

 

 

ADEPP, Depression after First Episode in Psychosis

The aim of the ADEPP trial is to establish the effectiveness and cost effectiveness of an antidepressant medication (sertraline) for prevention of a depressive episode following first episode psychosis.

Sertraline is a commonly used antidepressant which has been shown to prevent depression in other conditions. ADEPP is a multi-centre, double-blinded, randomised placebo controlled trial to investigate if taking sertraline in addition to usual treatment for 6 months after first episode psychosis can help to reduce the chances of depression as a preventative measure. The Lead Investigator for this study in LPT is Dr Shiraz Ahmed. Click here to find out more: https://www.birmingham.ac.uk/research/bctu/trials/pd/adepp/index.aspx

 

 

ImPreSs-care, Physical Health of Older People

ImPreSs-care aims to determine the physical health care needs of older adult patients under mental health services.

The rationale for this study is to improve the understanding of the physical health needs of older people under mental health services, and how we might be able to reduce admission to acute trusts through a geriatric liaison service.

 

 

MINDARISE, Mindfulness

MINDARISE is investigating if mindfulness may help with some of the stress that NHS staff are currently experiencing.

The study team aim to find out what NHS staff are already doing with mindfulness, whether it helps staff on a range of outcomes, and what can be optimised to help overcome the hurdles that staff face.

 

 

QPR, Inpatient Psychiatric Rehabilitation Services

This study hopes to find out what people think about a questionnaire regularly used in psychology: the 'Questionnaire About the Process of Recovery' (QPR).

This study is led by Chief Investigator Dr Kat Kidd in LPT, and is being conducted within the mental health inpatient rehabilitation service for adults. Patients complete the QPR as part of their treatment, this research aims to find out if this questionnaire is valid within this population.

 

 

LIRO, Psychiatric Rehabilitation Services

Leicestershire Inpatient Rehabilitation Outcomes (LIRO) aims to analyse data of service users who have accessed psychiatric rehabilitation services in Leicestershire.

LIRO aims to understand what helps individuals successfully progress from rehabilitation services into a community setting. Understanding outcomes is beneficial to patients accessing such services, service providers and commissioners. The study is led by Chief Investigator Dr Kelly Fenton in LPT.

 

 

Ethnic variations in outcomes of patients seen in Leicester memory service between 2002 and 2020, Memory Services

This study is investigating factors which differ between ethnic groups of patients seen in memory clinic, and whether outcomes differ by ethnicity.

Leicester has a large population of ethnic minorities. Understanding ethnic variations in outcomes of patients seen in memory services will be aid the design and development of dementia services for areas with a high proportion of patients presenting from Black and South Asian backgrounds. This research mat help to identify inequalities which can be addressed. This research is led by Dr Hari Subramaniam.

 

 

 

Resilient leadership through a gendered lens: A Qualitative study of the resilience strategies of senior female clinical psychology leaders, Leadership in Clinical Psychology

This study is investigating factors which differ between ethnic groups of patients seen in memory clinic, and whether outcomes differ by ethnicity.

Women often face different pressures than men when progressing into senior management.  As such it is argued that women may have different resilience strategies than men.  Moreover, there is very little research on public sector leaders in health care.  Clinical psychologists are one such group, who have distinct features that make their roles different to other healthcare professionals.  The aim of this study, therefore is to find out more about what resilience strategies senior female clinical psychologist leaders use. This research is being carried out by Marsha Towey, Trainee Clinical Psychologist.

The information on this page is correct as of January 2023.

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